Product Name | Molibresib (Synonyms: I-BET762; GSK525762; GSK525762A;I-BET-762) |
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CAS | 1260907-17-2 |
Formula | C22H22ClN5O2 |
MW | 423.90 |
MDL | MFCD22417091 |
Appearance | Off-white to yellow powder |
Storage condition | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Molibresib (I-BET-762, GSK525762, GSK525762A) is an inhibitor for BET proteins with IC50 of ~35 nM in a cell-free assay, suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation, highly selective over other bromodomain-containing proteins.
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