RMC-6236 | RAS-IN-2
RMC-6236 (Synonyms: RAS-IN-2)
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3-5 days
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$336.00
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Product Availability
3-5 days
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$788.00
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Product Availability
3-5 days
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$1180.00
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Product Overview
Product Name RMC-6236 (Synonyms: RAS-IN-2)
CAS2765081-21-6
FormulaC43H56N8O5S
MW797.02
AppearanceWhite to off-white powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Product details

RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.
RMC-6236 is an orally active, non-covalent RAS (ON) inhibitor. RMC-6236 disrupts the interaction of wild-type or mutant RAS proteins with the RAS binding domain of BRAF, with EC50 values ranging from 28-220 nM for wild-type KRAS, NRAS, HRAS, and multiple oncogenic RAS variants. RMC-6236 inhibits pERK. RMC-6236 has anti-tumor activity against KRAS mutant tumors.
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Related literature
PMID: 38593348 PMCID: PMC11149917 DOI: 10.1158/2159-8290.CD-24-0027
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