Product Name | CB-5083 |
---|---|
CAS | 1542705-92-9 |
Formula | C24H23N5O2 |
MW | 413.47 |
MDL | MFCD28963914 |
Appearance | White to light yellow powder |
Storage condition | Store short-term at 0-4°C or long-term at -20°C in a dry, dark place. |
CB-5083 is a first-in-class, potent, and orally bioavailable p97 inhibitor with a D2 site IC50 of 11 nM. It disrupts protein homeostasis, showing anti-tumor effects in solid and hematological cancers, and is more potent than current proteasome inhibitors.
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