西咪匹韦 | 司美匹韦 | 西米普韦
Simeprevir | TMC435 | HSDB 8227
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Product Availability
3-5days
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$108.00
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Product Availability
3-5days
Price
$168.00
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Product Availability
3-5days
Price
$266.00
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Product Overview
Product Name Simeprevir | TMC435 | HSDB 8227
CAS923604-59-5
FormulaC38H47N5O7S2
MW749.94
AppearanceWhite to off-white powder
Storage conditionStore in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.
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Product details

Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses.


Related
Simeprevir sodium | TMC435 sodium | TMC435350 sodium | Olysio
History
Simeprevir | TMC435 | HSDB 8227
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Teniposide (Synonyms: VM26)
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Etoricoxib (MK-663; MK-0663)
Rutaecarpine