Product Name | Simeprevir sodium | TMC435 sodium | TMC435350 sodium | Olysio |
---|---|
CAS | 1241946-89-3 |
Formula | C38H47N5O7S2.XNa |
MW | 749.94 (free) |
Simeprevir (TMC435; TMC435350) sodium is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir sodium inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir sodium also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir sodium inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses.
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