西咪匹韦钠 |西米普韦钠盐
Simeprevir sodium | TMC435 sodium | TMC435350 sodium | Olysio
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Product Name Simeprevir sodium | TMC435 sodium | TMC435350 sodium | Olysio
CAS1241946-89-3
FormulaC38H47N5O7S2.XNa
MW749.94 (free)
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Simeprevir (TMC435; TMC435350) sodium is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir sodium inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir sodium also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir sodium inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses.


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Simeprevir | TMC435 | HSDB 8227
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Simeprevir sodium | TMC435 sodium | TMC435350 sodium | Olysio
SRT 1720 monohydrochloride