Product Name | TG101209 |
---|---|
CAS | 936091-14-4 |
Formula | C26H35N7O2S |
MW | 509.67 |
Appearance | White to gray powder |
Storage condition | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET (c-RET) with IC50 of 25 nM and 17 nM in cell-free assays, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.
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