Product Name | Tivantinib | ARQ-197 |
---|---|
CAS | 905854-02-6 |
Formula | C23H19N3O2 |
MW | 369.42 |
Appearance | Light brown to brown powder |
Tivantinib is the first non-ATP-competitive c-Met inhibitor with Ki of 0.355 μM in a cell-free assay, little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. Tivantinib (ARQ 197) induces a G2/M arrest and apoptosis.
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