Product Name | PF-477736 | PF-736 | PF-00477736 |
---|---|
CAS | 952021-60-2 |
Formula | C22H25N7O2 |
MW | 419.48 |
PF-477736 (PF-736, PF-00477736) is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2.
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