Product Name | Darbufelone mesilate | CI-1004 mesylate |
---|---|
CAS | 139340-56-0 |
Formula | C18H24N2O2S·CH4O3S |
MW | 428.57 | 332.46 (free) |
Appearance | White to light yellow powder |
Storage condition | 4°C, sealed storage, away from moisture and light |
Darbufelone mesylate (CI-1004 mesylate) is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone potently inhibits PGHS-2 (IC50 = 0.19 μM) but is much less potent with PGHS-1 (IC50= 20 μM).
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