3-氨基-3-((4-氨基苯基)硫基)-2-(2-(三氟甲基)苯基)丙烯腈
SL 327
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Product Overview
Product Name SL 327
CAS305350-87-2
FormulaC16H12F3N3S
MW335.35
MDLMFCD06411432
AppearanceWhite to off-white powder
Storage conditionStore in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.
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Product details

SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII; capable of transport through the blood-brain barrier.


Related literature
PMID: 28954413 PMCID: PMC6151813 DOI: 10.3390/molecules22101551
PMID: 10541468 PMCID: PMC311312 DOI: 10.1101/lm.6.5.478
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History
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