Product Name | (R)-Roscovitine (Synonyms: Seliciclib; CYC202,细胞周期蛋白B激酶抑制剂;塞利西利) |
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CAS | 186692-46-6 |
Formula | C19H26N6O |
MW | 354.45 |
MDL | MFCD02266401 |
Appearance | White to off-white powder |
Storage condition | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Roscovitine is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 μM, 0.7 μM and 0.16 μM in cell-free assays. It shows little effect on CDK4/6.
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