Product Name | Ruxolitinib | INCB018424 | Ruxolitinib Free base | (R)-Ruxolitinib |
---|---|
CAS | 941678-49-5 |
Formula | C17H18N6 |
MW | 306.37 |
Appearance | White to light yellow powder |
Storage condition | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.
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