鲁索替尼 | 鲁索利替尼 | 芦可替尼
Ruxolitinib | INCB018424 | Ruxolitinib Free base | (R)-Ruxolitinib
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Product Name Ruxolitinib | INCB018424 | Ruxolitinib Free base | (R)-Ruxolitinib
CAS941678-49-5
FormulaC17H18N6
MW306.37
AppearanceWhite to light yellow powder
Storage conditionStore in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.
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Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.

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Ruxolitinib | INCB018424 | Ruxolitinib Free base | (R)-Ruxolitinib