SR-4835
SR-4835
ChemLeader
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5 mg 10 mg
Product Availability
3-5days
Price
$106.00
Member price
Product Availability
3-5days
Price
$166.00
Member price
Quantity
- +
Product Overview
Product Name SR-4835
CAS2387704-62-1
FormulaC21H20Cl2N10O
MW499.36
AppearanceOff-white to light brown powder
Storage conditionStore in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.
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Product details

SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors.


Related literature
PMID: 31668947 DOI: 10.1016/j.ccell.2019.09.004
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