6-(环丙烷甲酰胺基)-4-((2-甲氧基-3-(1-甲基-1H-1,2,4-三唑-3-基)苯基)氨基)-N-(甲基-D3)哒嗪-3-甲酰胺; 氘可来昔替尼 ; 德克拉维替尼 ; 酪氨酸蛋白激酶 TYK2 负异位调节剂
Deucravacitinib (Synonyms: BMS-986165)
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Product Overview
Product Name Deucravacitinib (Synonyms: BMS-986165)
CAS1609392-27-9
FormulaC20H19D3N8O3
MW425.46
MDLMFCD31715455
AppearanceOff-white to light yellow powder
Storage conditionStore in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.
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Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain.


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