Product Name | Deucravacitinib (Synonyms: BMS-986165) |
---|---|
CAS | 1609392-27-9 |
Formula | C20H19D3N8O3 |
MW | 425.46 |
MDL | MFCD31715455 |
Appearance | Off-white to light yellow powder |
Storage condition | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain.
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