HRO761 | Werner syndrome RecQ helicase-IN-1
HRO761 | Werner syndrome RecQ helicase-IN-1
ChemLeader
Catalog No:
CAS No.:
MDLNo:
Formula:
MW:
Size
1 mg 2 mg 5 mg
Product Availability
3-5days
Price
$126.00
Member price
Product Availability
3-5days
Price
$156.00
Member price
Product Availability
3-5days
Price
$266.00
Member price
Quantity
- +
Product Overview
Product Name HRO761 | Werner syndrome RecQ helicase-IN-1
CAS2869954-34-5
FormulaC31H31ClF3N9O5
MW702.08
AppearanceWhite to light yellow powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Security information
Product details

HRO761 is a potent, selective, allosteric inhibitor of Werner syndrome RecQ helicase (WRN). It binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation, and demonstrates anti-proliferative effects specifically in microsatellite instability (MSI) cancer cells.


Related literature
PMID: 38658754 PMCID: PMC11078746 DOI: 10.1038/s41586-024-07350-y
Related
Sorry, no related items
History
Pidilizumab (Anti-PDCD1 / PD-1 / CD279)
HRO761 | Werner syndrome RecQ helicase-IN-1
Lenacapavir (Synonyms: GS-6207)
PT-2385
Zalcitabine (ddC; Dideoxycytidine; 2',3'-Dideoxycytidine)
Asciminib (Synonyms: ABL001)
Photochlor(HPPH); HPPH
Mifamurtide | CGP-19835| MTP-PE | L-MTP-PE
Midostaurin | PKC412 | CGP 41231 | CGP 41251
24, 25-Dihydroxy VD2; 24,25-Dihydroxy vitamin D2;24,25-Dihydroxyvitamin D2; (4E,6R)-2,3-Dimethyl-6-[(1R,3aS,4E,7aR)-octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-7a-methyl-1H-inden-1-yl]-4-heptene-2,3-diol