| Product Name | HRO761 | Werner syndrome RecQ helicase-IN-1 |
|---|---|
| CAS | 2869954-34-5 |
| Formula | C31H31ClF3N9O5 |
| MW | 702.08 |
| Appearance | White to light yellow powder |
| Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
HRO761 is a potent, selective, allosteric inhibitor of Werner syndrome RecQ helicase (WRN). It binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation, and demonstrates anti-proliferative effects specifically in microsatellite instability (MSI) cancer cells.
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