HRO761 | Werner syndrome RecQ helicase-IN-1
HRO761 | Werner syndrome RecQ helicase-IN-1
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3-5days
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$126.00
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Product Availability
3-5days
Price
$156.00
Member price
Product Availability
3-5days
Price
$266.00
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Product Overview
Product Name HRO761 | Werner syndrome RecQ helicase-IN-1
CAS2869954-34-5
FormulaC31H31ClF3N9O5
MW702.08
AppearanceWhite to light yellow powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Product details

HRO761 is a potent, selective, allosteric inhibitor of Werner syndrome RecQ helicase (WRN). It binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation, and demonstrates anti-proliferative effects specifically in microsatellite instability (MSI) cancer cells.


Related literature
PMID: 38658754 PMCID: PMC11078746 DOI: 10.1038/s41586-024-07350-y
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History
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