Product Name | Carfilzomib (Synonyms: PR-171) |
---|---|
CAS | 868540-17-4 |
Formula | C40H57N5O7 |
MW | 719.91 |
MDL | MFCD11040997 |
Appearance | White to off-white powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.
This product is unstable in solution state. We recommend that you use it immediately.
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