(S)-4-甲基-N-((S)-1-(((S)-4-甲基-1-((R)-2-甲基氧基-2-基)-1-氧代戊烷-2-基)氨基)-1-氧代-3-苯基丙烷-2-基)-2-((S)-2-(2-吗啉乙酰氨基)-4-苯基丁胺基)戊酰胺;卡非佐米
Carfilzomib (Synonyms: PR-171)
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Product Overview
Product Name Carfilzomib (Synonyms: PR-171)
CAS868540-17-4
FormulaC40H57N5O7
MW719.91
MDLMFCD11040997
AppearanceWhite to off-white powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.


This product is unstable in solution state. We recommend that you use it immediately.

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History
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Carfilzomib (Synonyms: PR-171)
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