GDC-0879
GDC-0879 (Synonyms:AR-00341677)
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Product Name GDC-0879 (Synonyms:AR-00341677)
CAS905281-76-7
FormulaC19H18N4O2
MW334.37
AppearanceWhite to light brown powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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GDC-0879 is a highly selective, potent, and orally bioavailable RAF small-molecule inhibitor. In GDC-0879 -treated mice, both cell line- and patient-derived BRAF(V600E) tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant KRAS-expressing tumors.
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GDC-0879 (Synonyms:AR-00341677)
Becotatug | JMT-101