Product Name | PLX5622 |
---|---|
CAS | 1303420-67-8 |
Formula | C21H19F2N5O |
MW | 395.41 |
MDL | MFCD32201039 |
PLX5622, a highly selective CSF-1R inhibitor with an IC50 of < 10 nmol/L and over 20-fold selectivity over KIT and FLT3, is a brain-penetrant, orally active compound with an IC50 of 0.016 μM and a Ki of 5.9 nM. It enables targeted microglial cell elimination during pathology development and exhibits favorable pharmacokinetics across multiple animal species.
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