6-氟-N-((5-氟-2-甲氧基吡啶-3-基)甲基)-5-((5-甲基-1H-吡咯并[2,3-b]吡啶-3-基)甲基)吡啶 -2-胺;PLX5622
PLX5622
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1 mg 5 mg 10 mg 25 mg
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3-5 days
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$56.00
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Product Availability
3-5 days
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$138.00
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3-5 days
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$196.00
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3-5 days
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$326.00
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Product Overview
Product Name PLX5622
CAS1303420-67-8
FormulaC21H19F2N5O
MW395.41
MDLMFCD32201039
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PLX5622, a highly selective CSF-1R inhibitor with an IC50 of < 10 nmol/L and over 20-fold selectivity over KIT and FLT3, is a brain-penetrant, orally active compound with an IC50 of 0.016 μM and a Ki of 5.9 nM. It enables targeted microglial cell elimination during pathology development and exhibits favorable pharmacokinetics across multiple animal species.
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History
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