1,4-二氨基-2,3-二氰基-1,4-双(邻氨基苯巯基)丁二烯
U0126 (Synonyms: MEK1/2抑制剂 )
ChemLeader
Catalog No:
CAS No.:
MDLNo:
Formula:
MW:
Size
Quantity
- +
Product Overview
Product Name U0126 (Synonyms: MEK1/2抑制剂 )
CAS109511-58-2
FormulaC18H16N6S2
MW380.49
MDLMFCD11046040
AppearanceOff-white to light yellow powder
Storage conditionStore short-term at 0-4°C or long-term at -20°C in a dry, dark place.
Security information
Product details

U-0126, also known as Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile, is a potent and selective MEK inhibitor with IC50 values of 72 nM for MEK1 and 58 nM for MEK2. It effectively inhibits AP-1 transcription activity and is known to block the production of inflammatory cytokines and matrix metalloproteinases. U0126 is an autophagy and mitophagy inhibitor.

Related
Sorry, no related items
History
H-89
U0126 (Synonyms: MEK1/2抑制剂 )
Anti-TIM3 (cobolimab biosimilar) mAb