Product Name | Lapaquistat acetate (Synonyms: TAK-475) |
---|---|
CAS | 189060-13-7 |
Formula | C33H41ClN2O9 |
MW | 645.14 |
MDL | MFCD06407873 |
Appearance | White to off-white powder |
Storage condition | Store short-term at 0-4°C or long-term at -20°C in a dry, dark place. |
Lapaquistat acetate, a potent squalene synthase inhibitor, impedes the conversion of farnesyl diphosphate (FPP) to squalene, a key step in cholesterol synthesis. Utilized in treating Mevalonate Kinase Deficiency (MKD), an autosomal recessive disorder, it significantly reduces low-density lipoprotein cholesterol levels. However, its use may be accompanied by liver damage, a known side effect that warrants monitoring.
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