2-(1-(2-((3R,5S)-1-(3-乙酰氧基-2,2-二甲基丙基)-7-氯-5-(2,3-二甲氧基苯基)-2-氧代-1,2,3,5-四氢苯并[e][1,4]氧氮杂卓-3-基)乙酰基)哌啶-4-基)乙酸
Lapaquistat acetate (Synonyms: TAK-475)
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1 mg 2 mg 5 mg
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3-5 days
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Product Overview
Product Name Lapaquistat acetate (Synonyms: TAK-475)
CAS189060-13-7
FormulaC33H41ClN2O9
MW645.14
MDLMFCD06407873
Appearance White to off-white powder
Storage conditionStore short-term at 0-4°C or long-term at -20°C in a dry, dark place.
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Product details

Lapaquistat acetate, a potent squalene synthase inhibitor, impedes the conversion of farnesyl diphosphate (FPP) to squalene, a key step in cholesterol synthesis. Utilized in treating Mevalonate Kinase Deficiency (MKD), an autosomal recessive disorder, it significantly reduces low-density lipoprotein cholesterol levels. However, its use may be accompanied by liver damage, a known side effect that warrants monitoring.

 


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History
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