2-((S)-2-苄基-3-((3R,4R)-4-(3-羟基苯基)-3,4-二甲基哌啶-1-基)丙酰胺基)乙酸二水合物;爱维莫潘
Alvimopan dihydrate (Synonyms: ADL 8-2698 dihydrate; LY 246736 dihydrate)
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Product Name Alvimopan dihydrate (Synonyms: ADL 8-2698 dihydrate; LY 246736 dihydrate)
CAS170098-38-1
FormulaC25H36N2O6
MW460.56
MDLMFCD00927248
AppearanceWhite to off-white powder
Storage conditionStore short-term at 0-4°C or long-term at -20°C in a dry, dark place.
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Product details

Alvimopan dihydrate (ADL 8-2698 dihydrate) is a selective μ-opioid receptor antagonist with an IC50 of 1.7 nM, exhibiting high potency and oral activity. It demonstrates significant selectivity for the μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively), making it a valuable tool in postoperative ileus research.

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History
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Alvimopan dihydrate (Synonyms: ADL 8-2698 dihydrate; LY 246736 dihydrate)
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