N-(1-(8-((3-甲基-4-((1-甲基-1H-苯并[d]咪唑-5-基)氧基)苯基)氨基)嘧啶并[5,4-d]嘧啶-2-基)哌啶-4-基)丙烯酰胺;宗格替尼
Zongertinib (Synonyms: BI 1810631;BI 764532)
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Product Name Zongertinib (Synonyms: BI 1810631;BI 764532)
CAS2728667-27-2
FormulaC29H29N9O2
MW535.60
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Zongertinib (BI 1810631, BI 764532) is a selective and potent inhibitor of human HER2 and EGFR tyrosine kinase that covalently binds to both wild-type and mutated HER2 receptors, including exon 20 insertion mutations, while sparing EGFR signaling. It exhibits effective and tolerable oral treatment for patients with HER2 aberration-positive solid tumors.
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