3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮
RI-1 (Synonyms:RI1; RAD51 inhibitor 1)
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Product Name RI-1 (Synonyms:RI1; RAD51 inhibitor 1)
CAS415713-60-9
FormulaC14H11Cl3N2O3
MW361.61
MDLMFCD00814248
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RI-1 is a cell-permeable RAD51 inhibitor that binds covalently to the protein surface at Cysteine 319. RI-1 disrupts homologous recombination in human cells. RI-1 is a cell-permeable RAD51 inhibitor. RI-1 is a RAD51 inhibitor, with IC50s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells.
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History
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