| Product Name | RI-1 (Synonyms:RI1; RAD51 inhibitor 1) |
|---|---|
| CAS | 415713-60-9 |
| Formula | C14H11Cl3N2O3 |
| MW | 361.61 |
| MDL | MFCD00814248 |
RI-1 is a cell-permeable RAD51 inhibitor that binds covalently to the protein surface at Cysteine 319. RI-1 disrupts homologous recombination in human cells. RI-1 is a cell-permeable RAD51 inhibitor. RI-1 is a RAD51 inhibitor, with IC50s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells.
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