| Product Name | GW6471 |
|---|---|
| CAS | 880635-03-0 |
| Formula | C35H36F3N3O4 |
| MW | 619.67 |
| MDL | MFCD07784503 |
GW6471 is a PPARα antagonist, which completely inhibits GW409544-induced activation of PPARα with an IC50 = 0.24 μM. GW6471 induces a PPARα conformation that interacts efficiently with co-repressors.GW6471 prevents apoptosis and cell cycle arrest at G0/G1 in renal cell carcinoma. It reduces enhanced fatty acid oxidation and oxidative phosphorylation associated with glycolysis inhibition.
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