Product Name | Aflibercept (VEGF Trap) |
---|---|
CAS | 862111-32-8 |
Appearance | Colorless to light yellow liquid |
Storage condition | - 20℃ 3 years,-80°C for long term |
Aflibercept (VEGF Trap) is a soluble decoy Rapidly and dose-dependently elevated BP in mice and markedly impaired endothelial-dependent relaxation (EDR) and resulted in NADPH oxidases 1 (NOX1)- and NADPH oxidases 4 (NOX4)-mediated generation of ROS, decreased the activation of protein kinase B (Akt) and endothelial nitric oxide synthase (eNOS) concurrently with a reduction in nitric oxide (NO) production and elevation of ET-1 levels in mouse aortas.
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