Product Name | Anti-Human PCSK9 Monoclonal Antibody(Evolocumab); AMG 145 |
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CAS | 1256937-27-5 |
Appearance | Colorless to light yellow (Solution) |
Storage condition | Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. |
Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H2O2-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation.
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