Product Name | Sibeprenlimab (Synonyms: VIS649) |
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CAS | 2382896-07-1 |
Storage condition | store at -80°C | Shipping with blue ice. |
Sibeprenlimab (VIS649), a humanized IgG2 monoclonal antibody, neutralizes APRIL, a key factor in IgA nephropathy (IgAN) pathogenesis. It effectively reduces pathogenic IgA and IgM while preserving vaccine responses to SARS-CoV-2 mRNA-based vaccines. Clinical trials demonstrate that sibeprenlimab decreases UPCR and stabilizes GFR, positioning it as a promising treatment for IgAN.
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