N-((S)-1-(((2S,3S)-1-((6-氨基-6-氧代己基)氨基)-3-甲基-1-氧代戊烷-2-基)氨基)-3-(4-羟基苯基)-1-氧代丙烷-2-基)己酰胺 ;益智二肽
Dihexa (Synonyms: PNB-0408; N-hexanoic-Try-Ile-(6)-amino hexanoic amide; Hexanoyl-Tyr-Ile-Ahx-NH2)
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Product Name Dihexa (Synonyms: PNB-0408; N-hexanoic-Try-Ile-(6)-amino hexanoic amide; Hexanoyl-Tyr-Ile-Ahx-NH2)
CAS1401708-83-5
FormulaC27H44N4O5
MW504.66
MDLMFCD30533409
AppearanceWhite to gray white powder
Storage conditionStore at 0-4°C for short-term or -20°C for long-term in a dry, dark environment.
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Dihexa, an angiotensin IV analog, is a potent cognitive enhancer that crosses the BBB and binds to HGF with high affinity (Kd=65 pM), activating c-Met receptor pathways. It shows significant antidementia effects in animal models, suggesting therapeutic potential for Alzheimer's disease treatment.


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History
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