Chemleader Biomedical-Small Molecules 丨Intermediates 丨Drug Impurities

重组人白介素 18 (rHuIL-18)

Recombinant Human Interleukin 18 (rHulL-18)

ChemLeader 97%

Catalog No：CLRP1024

CAS No.：

MDLNo：

Formula：

MW：

Download MSDS

Size

25 µg

Product Availability

In-stock

Price

$390.00

Member price

Visible after login

Quantity

- +

Favorites

Inquiry Add To Cart

Product Overview

Product Name	Recombinant Human Interleukin 18 (rHulL-18)
Storage condition	Lyophilized samples are stable for 36 months from date of manufacture at -20℃ to -70℃. Upon reconstitution, this cytokine can be stored under sterile conditions at 2- 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Security information

Product details

Recombinant human IL-18 produced in yeast is a polypeptide chain containing 157 amino acids, with 4 Cys, but no disulfide bond.

Interleukin-18 (IL-18), also known as IL-1F4, is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature human IL-18 shares approximately 63% amino acid sequence identity with mouse and rat IL-18. IL-18 activation is induced by infection or tissue damage and leads to disease pathology in chronic inflammation. In the presence of IL-12 or IL-15, IL-18 enhances anti-viral Th1 immune responses by inducing IFN-gamma production and the cytolytic activity of CD8+ T cells and NK cells. IL-18 induces the antigen-independent production of IL-17 by gamma δ T cells and CD4+ T cells. IL-18 also promotes myeloid dendritic cell maturation and triggers neutrophil respiratory burst. In the absence of IL-12 or IL-15, IL-18 promotes production of the Th2 cytokines IL-4 and IL-13 by CD4+ T cells and basophils. IL-18 induces the antigen-independent production of IL-17 by gamma δ T cells and CD4+ T cells. IL-18 also promotes myeloid dendritic cell maturation and triggers neutrophil respiratory burst. In cancer, IL-18 has shown a variety of activities, including enhancing anti-tumor immunity, inhibiting or promoting angiogenesis, and promoting tumor cell metastasis.

Related literature

Sorry, no related items

History

DL-Lactide; 3,6-Dimethyl-1,4-dioxane-2,5-dione

$250.00

Recombinant Human Interleukin 18 (rHulL-18)

$390.00

Tamsulosin hydrochloride | (R)-(-)-YM12617 | LY253351

Inquiry

SGX-523

$66.00

Teneligliptin hydrobromide ( MP-513 hydrobromide)

Inquiry