雷公藤红素;南蛇藤素;南蛇藤醇
Celastrol (Synonyms: Tripterine; Tripterin)
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Product Overview
Product Name Celastrol (Synonyms: Tripterine; Tripterin)
CAS34157-83-0
FormulaC29H38O4
MW450.61
MDLMFCD03424073
AppearanceRed crystal powder
Storage conditionPowder: -20°C for 3 years | In solvent: -80°C for 1 year
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Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.
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History
Celastrol (Synonyms: Tripterine; Tripterin)
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