Product Name | Celastrol (Synonyms: Tripterine; Tripterin) |
---|---|
CAS | 34157-83-0 |
Formula | C29H38O4 |
MW | 450.61 |
MDL | MFCD03424073 |
Appearance | Red crystal powder |
Storage condition | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.
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