苦鬼臼毒素
Picropodophyllin (Synonyms: AXL1717; Picropodophyllotoxin; PPP)
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Product Overview
Product Name Picropodophyllin (Synonyms: AXL1717; Picropodophyllotoxin; PPP)
CAS477-47-4
FormulaC₂₂H₂₂O₈
MW414.41
AppearanceWhite to off-white powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Picropodophyllin (PPP, AXL1717) is a IGF-1R inhibitor with IC50 of 1 nM. It displays selectivity for IGF-1R and does not coinhibit tyrosine phosphorylation the IR, or of a selected panel of receptors less related to IGF-IR(FGF-R, PDGF-R, OR EGF-R). Picropodophyllin (PPP) induces apoptosis with antineoplastic activity.
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