高三尖杉酯碱
Homoharringtonine (Synonyms: CGX-635; Omacetaxine mepesuccinate; HHT; Myelostat; NSC 141633)
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Product Overview
Product Name Homoharringtonine (Synonyms: CGX-635; Omacetaxine mepesuccinate; HHT; Myelostat; NSC 141633)
CAS26833-87-4
FormulaC29H39NO9
MW545.62
MDLMFCD05618221
AppearanceOff-white to yellow powder
Storage condition 4°C, protect from light
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Homoharringtonine (Omacetaxine mepesuccinate; HHT) is a cytotoxic alkaloid derived from the Cephalotaxus tree, known for its significant antitumor properties. HHT acts primarily by inhibiting translation elongation, which disrupts protein synthesis crucial for cancer cell survival. This mechanism leads to the rapid degradation of several short-lived proteins, including Mcl-1 and c-Myc, triggering apoptosis in various cancer types, particularly in hematological malignancies such as acute myeloid leukemia (AML).
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Homoharringtonine (Synonyms: CGX-635; Omacetaxine mepesuccinate; HHT; Myelostat; NSC 141633)