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Gliquidone

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Catalog No：CL1154 CAS No.：33342-05-1 MDLNo： Formula：C27H33N3O6S MW：527.63

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
250 mg	In-stock	$350.00	Visible after login	- +
500 mg	In-stock	$660.00	Visible after login	- +
1 g	In-stock	$1100.00	Visible after login	- +

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Product Overview

Product Name	Gliquidone
CAS	33342-05-1
Formula	C27H33N3O6S
MW	527.63
Appearance	White crystalline powder odorless

Product details

Gliquidone (Glurenorm,AR-DF 26) is an ATP-sensitive K⁺ channel antagonist with IC50 of 27.2 nM.

Gliquidone is a second generation sulfonylurea that selectively inhibits ATP-sensitive potassium channel currents (IKATP) in pancreatic β-cells (IC50s = 0.45, 119.1, and 149.7 µM for HIT-T15 cells, cardiomyocytes, and vascular smooth muscle cells, respectively). It is also a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 10 μM in a transactivation assay). Gliquidone (0.2 nmol/g) decreases plasma levels of D-glucose and stimulates insulin release in anesthetized rats. It decreases blood glucose levels, serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activities, and hepatic lipid peroxidation and increases hepatic glutathione (GSH) levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg.

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CL1154

Gliquidone

33342-05-1 98+%