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Posaconazole (SCH 56592)

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Catalog No:CL2521 CAS No.:171228-49-2 MDLNo: Formula:C37H42F2N8O4 MW:700.78
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10 mg 3-5days $113.00 Visible after login
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25 mg 3-5days $163.00 Visible after login
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50 mg 3-5days $238.00 Visible after login
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Product Overview
Product Name Posaconazole (SCH 56592)
CAS171228-49-2
FormulaC37H42F2N8O4
MW700.78
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Product details

Posaconazole (also known as SCH 56592 or trade name of Noxafil) is a potent,broad-spectrum, second generation triazole antifungal compound that potently inhibits 14α-demethylation in a variety of fungi, including Candida and Aspergillus, with half maximal inhibition concentration IC50 of 0.007 μg/ml, 0.06 μg/ml, 0.2 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml respectively Posaconzole, an itraconzole derivative with fluorine replacing chlorine in the phenyl ring and hydroxylation in the side chain, binds to the heme cofactor on the active site of 14α-demethylase, which converts lanosterol to 14α-dimethy lanosterol, resulting in the disruption of the integrity and function of the fungal cell membrane and inhibition of fungal growth.

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