Pepstatin(Pepstatin A)

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
10 mg	3-5days	$125.00	Visible after login	- +
25 mg	3-5days	$188.00	Visible after login	- +
50 mg	3-5days	$350.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

10 mg

3-5days

$125.00

Visible after login

- +

25 mg

3-5days

$188.00

Visible after login

- +

50 mg

3-5days

$350.00

Visible after login

- +

Product Overview

Product Name	Pepstatin(Pepstatin A)
CAS	26305-03-3
Formula	C34 H63N5O9
MW	685.89
Appearance	White to off-white
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Pepstatin A (NSC-272671; NSC272671), a pentapeptide, is a potent and selective aspartic protease inhibitor which also inhibits HIV replication. Pepstatin A was originally isolated from the microbe. For the enzymes hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease, and hemoglobin-acid protease, respectively, its IC50 values are 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM, and 260 nM. At weak acid pH values, pepstatinA, a highly potent renin inhibitor, inhibited both human and porcine renin with IC50 values of 15 μM and 0.32, respectively. For aspartic proteinases like pepsin, cathepsins D and E, pepstatin A effectively inhibits them. Pepstatin A appears to have no harmful effects on HIV-infected cells, but it does block a portion of the intracellular processing of the HIV gag protein in H9 cells that have the virus. By preventing ERK signaling and reducing NFATc1 expression, pepstatin A also prevents osteoclast differentiation.

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History

CLP1109

Pepstatin(Pepstatin A)

26305-03-3 98+%