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Doxorubicin(Adriamycin) Hydrochloride

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Catalog No：CL1004 CAS No.：25316-40-9 MDLNo： Formula：C27H29NO11.HCl MW： 579.98

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
100 mg	In-stock	$220.00	Visible after login	- +
500 mg	In-stock	$500.00	Visible after login	- +
1 g	In-stock	$800.00	Visible after login	- +

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Product Overview

Product Name	Doxorubicin(Adriamycin) Hydrochloride
CAS	25316-40-9
Formula	C27H29NO11.HCl
MW	579.98
Appearance	Orange red powder
Storage condition	Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

Product details

Doxorubicin is an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.

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CL1004

Doxorubicin(Adriamycin) Hydrochloride

25316-40-9 98+%