Product Name | GSK2606414;GSK 2606414 |
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CAS | 1337531-36-8 |
Formula | C24H20F3N5O |
MW | 451.44 |
Appearance | white powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Size | Availability | Price(USD) | VIP Price (USD) | Quantity |
---|---|---|---|---|
20 mg | 3-5days | $500.00 | Visible after login | |
50 mg | 3-5days | $550.00 | Visible after login | |
100 mg | 3-5days | $800.00 | Visible after login |
Product Name | GSK2606414;GSK 2606414 |
---|---|
CAS | 1337531-36-8 |
Formula | C24H20F3N5O |
MW | 451.44 |
Appearance | white powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
GSK2606414 is an orally available, selective protein kinase R-like ER kinase (PERK) inhibitor with an IC50 value of 0.4 nM. It can inhibit thapsigargin-induced PERK phosphorylation in lung carcinoma A549 cells and attenuates subcutaneous pancreatic human tumor xenograft growth in mice. Because PERK mediates the unfolded protein response pathway, which has roles in neurotoxicity and cancer, inhibition of PERK signaling has potential applications for the treatment of cancer and also cognitive degeneration.