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Combretastatin A4 Disodium Phosphate(CA4P)

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Catalog No:CL2386 CAS No.:168555-66-6 MDLNo: Formula:C18H19PO8Na2 MW:440.29
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Product Overview
Product Name Combretastatin A4 Disodium Phosphate(CA4P)
CAS168555-66-6
FormulaC18H19PO8Na2
MW440.29
Appearancewhite powder
Storage conditionDry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Product details

Fosbretabulin (Combretastatin A4 Phosphate, CA4P, CA 4DP) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.

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