Oclacitinib Maleate (PF-03394197 Maleate

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Product Overview

Product Name	Oclacitinib Maleate (PF-03394197 Maleate)
CAS	1640292-55-2
Formula	C19H27N5O6S
MW	453.51
Appearance	White to off-white powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Oclacitinib maleate (formerly PF-03394197 maleate) is a novel and potent inhibitor of JAK (Janus kinase) family members with IC50 values ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM. Oclacitinib did not inhibit a panel of 38 non-JAK kinases and is the most potent at inhibiting JAK1. Oclacitinib also inhibits the function of JAK1-dependent cytokines involved in allergy and inflammation as well as pruritus. Cclacitinib is a targeted therapy that selectively inhibits JAK1-dependent cytokines involved in allergy, inflammation, and pruritus and suggests these are the mechanisms by which oclacitinib effectively controls clinical signs associated with allergic skin disease in dogs.

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History

CL2531

Oclacitinib Maleate (PF-03394197 Maleate)

1640292-55-2 98+%

Oclacitinib Maleate (PF-03394197 Maleate)

Chemical safety data sheet(MSDS)