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Y-27632 Dihydrochloride; Y-27632 2HCl

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Catalog No：CL1003 CAS No.：129830-38-2 MDLNo： Formula：C14H21N3O.2HCl MW：320.26

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	In-stock	$400.00	Visible after login	- +
10 mg	In-stock	$550.00	Visible after login	- +
25 mg	In-stock	$800.00	Visible after login	- +
50 mg	In-stock	$900.00	Visible after login	- +

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Product Overview

Product Name	Y-27632 Dihydrochloride; Y-27632 2HCl
CAS	129830-38-2
Formula	C14H21N3O.2HCl
MW	320.26
Appearance	White to off-white solid powder

Product details

The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 is a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM. One-hour treatment with 10 µM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages.

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CL1003

Y-27632 Dihydrochloride; Y-27632 2HCl

129830-38-2 98+%