Abemaciclib Mesylate(LY2835219 Mesylate)

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Price(USD)

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Product Overview

Product Name	Abemaciclib Mesylate(LY2835219 Mesylate); Abemaciclib Methanesulfonate
CAS	1231930-82-7
Formula	C28H36F2N8O3S
MW	602.70
Appearance	White to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.

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History

CL1153

Abemaciclib Mesylate(LY2835219 Mesylate); Abemaciclib Methanesulfonate

1231930-82-7 98+%

Abemaciclib Mesylate(LY2835219 Mesylate); Abemaciclib Methanesulfonate

Chemical safety data sheet(MSDS)