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BPTES

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Catalog No：CL1972 CAS No.：314045-39-1 MDLNo： Formula：C24H24N6O2S3 MW：524.68

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Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	In-stock	$220.00	Visible after login	- +
10 mg	In-stock	$300.00	Visible after login	- +
25 mg	In-stock	$530.00	Visible after login	- +
50 mg	In-stock	$960.00	Visible after login	- +
100 mg	In-stock	$1750.00	Visible after login	- +

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Product Overview

Product Name	BPTES
CAS	314045-39-1
Formula	C24H24N6O2S3
MW	524.68
Appearance	White powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

BPTES is an allosteric inhibitor of kidney-type glutaminase 1 (GLS1; IC50 = 3.3 μM) that drives the formation of inactive GLS1 tetramers. It is selective for GLS1 over GLS2, glutamate dehydrogenase, and γ-glutamyl transpeptidase. BPTES decreases glutaminase activity and reduces proliferation of aerobic P493 cells as well as induces cell death, increases the production of reactive oxygen species (ROS), and reduces ATP levels in hypoxic P493 cells. It also decreases ATP-linked and uncoupled oxygen consumption in C2C12 myotubes when used in combination with UK 5099 and/or etomoxir. In vivo, BPTES (12.5 mg/kg) reduces tumor volume in a P493 lymphoma mouse xenograft model.

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CL1972

BPTES

314045-39-1 98+%