Product Name | Celastrol (Tripterin); Tripterine |
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CAS | 34157-83-0 |
Formula | C29H38O4 |
MW | 450.61 |
Appearance | Red crystal powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
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Product Name | Celastrol (Tripterin); Tripterine |
---|---|
CAS | 34157-83-0 |
Formula | C29H38O4 |
MW | 450.61 |
Appearance | Red crystal powder |
Storage condition | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Celastrol is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy.