Streptozotocin | Streptozocin | Streptozocin | NSC-85998 | U 9889 | CAS: 18883-66-4

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
50 mg	In-stock	$66.00	Visible after login	- +
100 mg	In-stock	$88.00	Visible after login	- +
200 mg	In-stock	$156.00	Visible after login	- +

Size

Availability

Price(USD)

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Quantity

50 mg

In-stock

$66.00

Visible after login

- +

100 mg

In-stock

$88.00

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- +

200 mg

In-stock

$156.00

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- +

Product Overview

Product Name	Streptozotocin (Synonyms: Streptozocin; Streptozocin; NSC-85998; U 9889)
CAS	18883-66-4
Formula	C8H15N3O7
MW	265.22
MDL	MFCD00006607
Appearance	Light yellow powder
Storage condition	-20°C, sealed storage, away from moisture and light

Product details

Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals. It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. DNA damage induces activation of poly ADP-ribosylation, depletion of cellular NAD+ and ATP, and formation of superoxide radicals, leading to the destruction of beta cells.The effectiveness of STZ depends on the level of GLUT2 expression, which in turn may be influenced by age, sex, strain, or species.

Related literature

Outbred Mice with Streptozotocin-Induced Diabetes Show Sex Differences in Glucose Metabolism.

Int J Mol Sci. 2023 Mar 8;24(6):5210.

Streptozotocin-Induced Diabetic Models in Mice and Rats.

PMID: 26331889 DOI: 10.1002/0471141755.ph0547s70

Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies.

PMID: 25573197 DOI: 10.1016/j.imlet.2014.12.006

Antidiabetic effect of a new peptide from Squalus mitsukurii liver (S-8300) in streptozocin-induced diabetic mice.

PMID: 16354401 DOI: 10.1211/jpp.57.12.0007

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History

CL1016