Inavolisib | GDC-0077 | RG6114 | RO-7113755

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
1 mg	3-5days	$188.00	Visible after login	- +
5 mg	3-5days	$526.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

1 mg

3-5days

$188.00

Visible after login

- +

5 mg

3-5days

$526.00

Visible after login

- +

Product Overview

Product Name	Inavolisib \| GDC-0077 \| RG6114 \| RO-7113755
CAS	2060571-02-8
Formula	C18H19F2N5O4
MW	407.37
Appearance	White to yellow powder
Storage condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

Product details

GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC₅₀=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutant versus wild-type PI3Kα.

Related literature

Abstract PD4-14: GDC-0077 is a selective PI3Kalpha inhibitor that demonstrates robust efficacy in PIK3CA mutant breast cancer models as a single agent and in combination with standard of care therapies.

https://doi.org/10.1158/1538-7445.SABCS17-PD4-14

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.

PMID: 36455032 DOI: 10.1021/acs.jmedchem.2c01422

RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy.

PMID: 34544753 PMCID: PMC9762331 DOI: 10.1158/2159-8290.CD-21-0072

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History

CL1233

Inavolisib | GDC-0077 | RG6114 | RO-7113755

2060571-02-8 98+%

Inavolisib | GDC-0077 | RG6114 | RO-7113755

Chemical safety data sheet(MSDS)