GS-9973| Entospletinib | 1229208-44-9

Size	Availability	Price(USD)	VIP Price (USD)	Quantity
5 mg	3-5days	$88.00	Visible after login	- +
10 mg	3-5days	$146.00	Visible after login	- +

Size

Availability

Price(USD)

VIP Price (USD)

Quantity

5 mg

3-5days

$88.00

Visible after login

- +

10 mg

3-5days

$146.00

Visible after login

- +

Product Overview

Product Name	Entospletinib \| GS-9973
CAS	1229208-44-9
Formula	C23H21N7O
MW	411.46
Appearance	White to gray powder
Storage condition	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

Product details

Entospletinib (GS-9973) is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM in a cell-free assay and showed 13- to >1000-fold cellular selectivity for Syk over other kinases(including Jak2, ckit, Flt3, Ret, KDR) as assessed by target protein phosphorylation or functional response.

Related literature

Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase.

PMID: 24779514 DOI: 10.1021/jm500228a

A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor.

PMID: 24659719 PMCID: PMC4011593 DOI: 10.18632/oncotarget.1484

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History