Product Name | Alectinib Hydrochloride (Synonyms: CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride;Alectinib HCl) |
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CAS | 1256589-74-8 |
Formula | C30H35ClN4O2 |
MW | 519.08 |
MDL | MFCD27987893 |
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Product Name | Alectinib Hydrochloride (Synonyms: CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride;Alectinib HCl) |
---|---|
CAS | 1256589-74-8 |
Formula | C30H35ClN4O2 |
MW | 519.08 |
MDL | MFCD27987893 |
Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively. Alectinib demonstrates effective central nervous system (CNS) penetration.