Pazopanib | GW786034 | CAS 444731-52-6

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Product Overview

Product Name	Pazopanib (Synonyms: GW786034)
CAS	444731-52-6
Formula	C21H23N7O2S
MW	437.52
Appearance	White powder
Storage condition	Store in a tightly closed container in a cool and dry place

Product details

Pazopanib (GW-786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.An oral angiogenesis inhibitor targeting VEGFR and PDGFR.A potent and selective inhibitor of tyrosine kinases, targeting VEGFR/c-KIT/PDGFR, blocking angiogenesis; as an oral antineoplastic agent.
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Related literature

Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.

PMID: 18620382 DOI: 10.1021/jm800566m

Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage.

PMID: 21945644 PMCID: PMC3233473 DOI: 10.1016/j.mvr.2011.09.001

CL1636A

Pazopanib Hydrochloride (Synonyms: GW786034 Hydrochloride; Pazopanib HCl; GW786034 HCl)

635702-64-6 99+%

History

CL1636

Pazopanib (Synonyms: GW786034)

444731-52-6 99+%

Pazopanib (Synonyms: GW786034)

Chemical safety data sheet(MSDS)