Ridaforolimus (Synonyms: MK-8669; Deforolimus; AP23573; 42-(二甲基亚膦酰)雷帕霉素);CAS:572924-54-0

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Product Overview

Product Name	Ridaforolimus (Synonyms: MK-8669; Deforolimus; AP23573; 42-(二甲基亚膦酰)雷帕霉素)
CAS	572924-54-0
Formula	C53 H84 N O14 P
MW	990.21
MDL	MFCD13184816
Appearance	White to light yellow powder

Product details

Ridaforolimus (MK-8669) is a potent and selective mTOR inhibitor; inhibits ribosomal protein S6 phosphorylation with an IC₅₀ of 0.2 nM in HT-1080 cells.

Related literature

Deforolimus (AP23573; MK-8669), a potent mTOR inhibitor, has broad antitumor activity and can be optimally administered using intermittent dosing regimens.

PMID: 21482695 DOI: 10.1158/1535-7163.MCT-10-0792

mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis.

PMID: 29275959 DOI: 10.1016/j.cmet.2017.11.006

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History

CL1761

Ridaforolimus (Synonyms: MK-8669; Deforolimus; AP23573; 42-(二甲基亚膦酰)雷帕霉素)

572924-54-0 98+%