Home > Category > Signaling Pathways > GPCR & G Protein > CXCR > Plerixafor Octahydrochloride (Synonyms: AMD3100 Octahydrochloride; JM3100 octahydrochloride; SID791 octahydrochloride;Plerixafor 8HCl;AMD3100 8HCl)

Plerixafor Octahydrochloride (Synonyms: AMD3100 Octahydrochloride; JM3100 octahydrochloride; SID791 octahydrochloride;Plerixafor 8HCl;AMD3100 8HCl)

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Catalog No：CL1810 CAS No.：155148-31-5 MDLNo： Formula：C28H54N8.8HCl MW：794.47

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Product Overview

Product Name	Plerixafor Octahydrochloride (Synonyms: AMD3100 Octahydrochloride; JM3100 octahydrochloride; SID791 octahydrochloride;Plerixafor 8HCl;AMD3100 8HCl)
CAS	155148-31-5
Formula	C28H54N8.8HCl
MW	794.47
Appearance	White to yellow powder
Storage condition	S4°C, sealed storage, away from moisture

Product details

Plerixafor octahydrochloride (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC₅₀ of 44 nM.

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Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model.

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Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands.

PMID: 19641136 DOI: 10.4049/jimmunol.0900269

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Continuous AMD3100 Treatment Worsens Renal Fibrosis through Regulation of Bone Marrow Derived Pro-Angiogenic Cells Homing and T-Cell-Related Inflammation.

PMID: 26900858 PMCID: PMC4763993 DOI: 10.1371/journal.pone.0149926

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